Brief Items of Interest, January 2017

Hair loss news 1st:

— Replicel’s CEO offered a detailed 2017 forecast, and this was followed up by the release of an important PowerPoint presentation in which the organization summarized final five-year security and efficacy information for their RCH-01 solution. Essential locating: “mean alter in total hair density at 6-months = six.1% vs five.% target“. 70 % of responders saw a 14.3% typical boost in density at 6-months. While they did not mention 12-month RCH-01 final results, they do point out 12-month outcomes from Finasteride (7-14% increase in hair density) and Minoxidil (eight-16% increase in hair density) for comparison. Also, Replicel companion Shiseido’s Japanese clinical research findings are expected in 2018 along with a prospective solution launch in the identical year.

— Aclaris Therapeutics produced but an additional presentation (pdf downloadable from their press releases page — I did not listen to the webcast), this time at the 35th Annual JP Morgan Healthcare Conference. At the finish of the report they mention that pre-clincial improvement is now underway for their topical ATI-50003 selective covalently binding JAK 3 inhibitor to treat androgenetic alopecia. Nonetheless, nothing in the report mentions when they aim to start phase 1 clinical trials. I hope it will be prior to the end of 2017.

— Follicum announced patent approvals in Russia and in Japan. The firm had earlier also announced that they have been scheduled to comprehensive the multiple dose part of their clinical phase I/IIa study in January 2017 at the prestigious Charité University Hospital in Berlin.

— Judging from the latest update from Fidia Farmaceutici (Italy), The Dr. Brotzu lotion will not come out as early as some individuals expected, and a lot of individuals on the forums got mad (but a few took it as a positive sign that Fidia is lastly releasing dates even if ambiguous — “development of the potential product candidate being completed by 2018“). Ever because I initial wrote about Dr. Brotzu, I have not paid significantly focus to this product, but if you are inclined, go by way of the final 50 or so pages of this record breaking HLT thread and verify out the different Italian hair loss forums out there.

— Also from Italy, some kind of PRP plus insulin variety of treatment (challenging to tell for certain after translation).

— Researchers identify how skin cells grow to be hairy or sweaty during the embryonic stage of development. Actual study.

— This guy got a hairpiece and over 2 million youtube views in the procedure. He is almost certainly a person popular, but I did not feel like carrying out any background research or even watching most of the video.

And now on to medical items of interest:

— From a team led by the most popular hair loss researcher in the world Dr. George Cotsarelis (who has been at it for at least 20 years), comes a new study on how to heal wounds without having leaving any residual scars. Essential quote from Dr. Cotsarelis: “Essentially, we can manipulate wound healing so that it leads to skin regeneration rather than scarring. The secret is to regenerate hair follicles first. Right after that, the fat will regenerate in response to the signals from these follicles”. I have discussed the link between fat cells and hair cells numerous occasions on this blog, like in the the last post on the arrector pili muscle. These latest findings were widely covered by the worldwide media, with headlines such as “The Finish of Scars“. The Reddit thread on this blew up. Nonetheless, as with all factors Cotsarelis, headline stealing findings, but one particular always gets the feeling that sensible use will be at least a decade away unless other labs get in on the action.

— Babies born without having mothers (via embryos made from male skin cells) will come sooner than anticipated warn scientists. Surreal.

— Designer babies: an ethical horror waiting to occur? I am all for it even if it turns out horrific.

— Alzheimer’s drug “tideglusib” aids rotten teeth regenerate, minimizing the want for fillings.

— Chinese company implants 3D prints blood vessels into monkeys.

The Finish of Hair Loss and Balding by 2020



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