Kenogen: A New Phase of the Hair Cycle?

Earlier this month, an intriguing new study was published in the Experimental Dermatology journal by UK based scientists. The title of this study was “Hair regrowth in male and female pattern hair loss does not involve the conversion of vellus hair to terminal hair“.

Essentially, the scientists found that when medications such as minoxidil, finasteride and anti-androgens have been utilised to treat hair loss individuals (each men and females), the resulting hair regrowth was virtually entirely attributable to the reactivation of dormant non-vellus hair follicles (termed as “kenogen” hair follicles) rather than the conversion of fine miniaturized vellus hair into thick terminal hair.

This is a really surprising locating considering that in both male pattern hair loss (MPHL) and female pattern hair loss (FPHL), terminal hair miniaturizes via shorter and shorter development cycles and finally becomes vellus virtually invisible fine hair. I am quite particular that it has extended been assumed that hair loss medications lead to some of these vellus hair to grow to be terminal hair as soon as once more (if I have time later this week, I will attempt to discover research in assistance of such a theory). Nevertheless, this newest study suggests anything entirely distinct by concluding that:

We would propose there is a population of growth restricted (dormant/kenogen) non-vellus hair follicles, which are re-activated by successful healthcare therapies as an explanation for the enhanced hair development observed in FPHL and MPHL. Our findings have a fundamental influence on the pathophysiology of hair changes occurring in patterned hair loss.

Hair Follicle Growth Cycle and Phases

We have all heard of the three main phases of the hair follicle development cycle in anagen (development), catagen (transition/regression) and telogen (resting). There is also a lesser known phase called exogen, which is when hair follicles undergo shedding

Even so, I had in no way heard of this new kenogen phase ahead of. A simple google search showed that although this phase is nearly by no means pointed out in literature, it was discovered as early as in 2002 when a study titled “Kenogen. A new phase of the hair cycle?” was published in Italy.

I am not certain if just many research on this are adequate to make any conclusions, but it is difficult to think that there could be some follicles in a dormant state that were previously unaccounted for and that are becoming reactivated by hair loss medicines.

The End of Hair Loss and Balding by 2020



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